BENGALURU: A newly identified gene may hold the key to preventing a type of fungal infection – candidiasis – that most often affects the intensive care unit.ICU) patients, cancer patients and patients receiving immunosuppressive therapy.
Scientists at Jawaharlal Nehru Center for Advanced Scientific Research, Bangalore (JNCASR) and the Institut Pasteur, Paris, France have identified a gene called “CSA6” in Candida albicans (C. albicans), a fungal species with high rates of morbidity and mortality under certain immune-compromised conditions such as AIDS or Infamous for being born. During cancer treatment.
As per the Department of Science and Technology (DST) – JNCASR is an autonomous institute dst – Fungal species living in the mucosal lining (the moist, inner lining of some organs and body cavities) of the gastrointestinal and urogenital tracts of healthy individuals are transformed into a pathogen under immune-compromised conditions, allowing host defenses to be superficial as well as life-threatening. poses a danger to. systemic infection.
In a recent collaborative study between prof. Kaustuv SanyalGroups in JNCASR and Christophe DeeEnfertIn the Institut Pasteur’s group, the authors carried out a large-scale screen to identify regulators of chromosome stability in a clinically relevant fungal model system, C. albicans.
“The authors of JNCASR individually examined the effect of overexpression of over 1,000 genes of C. albicans on genome stability and were successful in identifying a set of six chromosomal stability (CSA) genes that are involved in maintaining genome integrity. important,” DST said.
While five of the identified csA genes are known to be important for cell division in other species, the sixth csA gene – CsA6 – encodes for a protein that is involved in C. albicans is essential for viability.
“They found that CSA6 was an important regulator of cell cycle progression, with both overexpression and deletion of CSA6 reducing the growth of C. albicans cells. The study published in the journal nature communication The human fungal pathogen C. albicans represents the first report of such a widespread screen,” DST said.
It added that the study identifies and elucidates the functions of a novel regulator of chromosome stability that is specifically present in a group of clinically relevant human fungal pathogens.
“In addition, it also provides a systematic plan to identify genes whose products may serve as potential therapeutic interventions for fungal infections with less adverse effects on humans. Hence, the small molecule modulator called Csa6.” alter gene expression levels, providing potential avenues of treatment in humans without any side effects,” said DST.